Published on January 25, 2024 Updated on February 13, 2024

N. Mejhert, K. R. Gabriel, S. Frendo-Cumbo, N. Krahmer, J. Song, L. Kuruvilla, C. Chitraju, S. Boland, D.K. Jang, M. von Grotthuss, M.C. Costanzo, M. Rydén, J. A. Olzmann, J. Flannick, N.P. Burtt, R.V. Jr Farese, T.C. Walther (2022)

Abstract

Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid storage, such as atherosclerosis, obesity, type 2 diabetes, and hepatic steatosis. Consequently, there is an increasing need for a resource that combines datasets from systematic analyses of LD biology. Here we integrate high-confidence, systematically generated human, mouse and fly data from on studies of LDs in the framework of an online platform named the Lipid Droplet Knowledge Portal (https://lipiddroplet.org/). This scalable and interactive portal includes comprehensive datasets, across a variety of cell types, for LD biology, including transcriptional profiles of induced lipid storage, organellar proteomics, genome-wide screen phenotypes, and ties to human genetics. This resource is a powerful platform that can be utilized to identify determinants of lipid storage.