Expertise: Biochemistry of protein membrane interactions through reconstitution approaches. Our aim in SPHERES is to get a quantitative view of the surface of LD in adipocytes in term of protein and lipid composition, relative surface occupancy, domain formation and dynamics, and reactivity to lipases.
(c)Bruno-Antonny
Ana Rita Dias Araujo
Research Engineer, IPMC.
Field of expertise: lipidomics (TLC, LC-MS), protein mistranslation, fungicide resistance and related method development. My contribution to the ERC will be mostly: lipid analysis and TLC method development, and adypocyte/spheroid culture establishment and maintenance in our lab.
Ana_Rita_Dias_Araujo
Akim Bello
PhD Student, IPMC.
After a master in biology from the faculté des sciences de Limoges, Akim first joined the team in June 2021 as an engineer in charge of the spheroid cultures, the purification of lipid droplet-associated proteins and the associated development. In Feb 2023, Akim enrolled in the PhD programme. He studies the interfacial biochemistry of perilipins, lipases and other LD associated proteins.
(c)Akim_Bello
Romain Gautier
Assistant professor, IPMC.
Molecular Dynamics Simulations - Structural Bioinformatics - Molecular Modeling - Membranes Structures - Amphipathic Helices. Aim in SPHERES is to get an atomic view of protein lipid interactions at the surface of LDs.
Romain_Gautier
Lucile Fleuriot
Engineer, IPMC.
Lucile Fleuriot is an engineer from the Ecole européenne d'ingénieurs de chimie, polymères et matériaux (ECPM), Université de Strasbourg. She is in charge of the lipidomic analysis by mass spectrometry.
Joëlle Bigay
Researcher, IPMC.
Area of expertise: Biochemistry, Reconstituted system study of protein / membrane interactions (purified proteins / liposomes of defined composition) or of lipid transport activity (in particular cholesterol / Pi4P exchange by OSBP) between two types of membranes (membrane contact sites). Contribution to the project: interaction of proteins on the surface of lipid droplets, notably lipid transfer proteins.
Joelle Bigay
Delphine Debayle
Engineer, Chemist, in charge of the lipidomic platform, IPMC.
My contribution to the project will be through lipidomic analyzes, in particular by mass spectrometry.
Delphine_Debayle
David Kovacs
Postdoc researcher, IPMC.
Cell biology of lipid transfer proteins, cholesterol transport, cell motility and migration, proximity biotinylation. Contribution: setting up the 3D adipocyte culture system in the Antonny lab.
Cell Biology and biochemistry of perilipins. Aim in SPHERES is to better understand the relative roles of the various perilipins (notably Plin1 and Plin4) and their domains on the function of the LD in the mature adipocyte.
Alenka-Copic
Céline Franckhauser
IE, CRBM.
Céline is an expert in protein purification, biochemistry and cell biology. She is also the lab manager in the team of Alenka Copic.
Céline Franckauser
Charbel Choufani
IE, CRBM.
Charbel did a master 2 in quantitative biology at the University of Montpellier. He was hired in the lab as an engineer in Oct 2022. He studies the structure of perilipin 4 and develops AFM approaches at the surface of lipid droplets.
Bayane Sebbagh
PhD student, CRBM.
I am a PhD student in the group of Alenka Copic since February 2022. In my PhD project, I will study the structure and the function of perilipin 4 and its interaction with lipid droplets in adipocytes as well as in vitro.