Published on February 27, 2025–Updated on April 4, 2025
H. Gao, P. Arner, G. Beauchef, C. Guere, K. Vie, I. Dahlman, N. Mejhert, M. Rydén (2020)
Abstract
Adipocyte lipolysis is an enzymatically regulated process that hydrolyzes stored triacylglycerols into free fatty acids and glycerol (Arner et al., 2018). It is primarily stimulated by catecholamines (noradren- aline and adrenaline) acting through beta-adrenoceptors. Ligand binding to these receptors results in increased intra- cellular levels of cyclic AMP (cAMP), which in turn stimulates protein kinase A and lipase activity. Attenuated catechol- amine-induced lipolysis negatively impacts lipid turnover, promotes white adipose tissue (WAT) accumulation,reduces the ability to withstand starvation, and may also affect the ability to maintain core body temperature (Arner et al., 2018; Ryde´ n et al., 2020; Toth and Tchernof, 2000). Importantly, these are all features commonly observed with ag- ing (Lo¨ nnqvist et al., 1990; Ryde´ n et al., 2020).
